Cellosaurus cell line 786-O/GFP (CVCL

Cellosaurus 786-O/GFP (CVCL_E6XL)

Entry history
Cell line name	786-O/GFP
Synonyms	786-O / GFP
Accession	CVCL_E6XL
Resource Identification Initiative	To cite this cell line use: 786-O/GFP (RRID:CVCL_E6XL)
Comments	Population: Caucasian. Characteristics: Transduced by lentivirus with a EF1a-eGFP-Rsv-PuroR construct (GenTarget=SC069-G). Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP). Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations	Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; c.560-2A>G; ClinVar=VCV003148158; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (from parent cell line).
Disease	Renal cell carcinoma (NCIt: C9385) Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1051 (786-O)
Sex of cell	Male
Age at sampling	58Y
Category	Cancer cell line
Web pages	Provider; GenTarget; SC069-G; https://www.gentarget.com/product/human-786-o-gfp-stable-cells/
Entry creation	10-Apr-2025
Last entry update	14-Aug-2025
Version number	2