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Cellosaurus KU812 IM1 (CVCL_E6I5)

[Text version]
Cell line name KU812 IM1
Synonyms KU812 2microM IM1
Accession CVCL_E6I5
Resource Identification Initiative To cite this cell line use: KU812 IM1 (RRID:CVCL_E6I5)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Basophil progenitor cell; CL=CL_0000613.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:76; ABL1; Simple; p.Glu450Gln (c.1348G>C); Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=21718141).
  • Mutation; HGNC; HGNC:76; ABL1; Simple; p.Glu459Lys (c.1375G>A); Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=21718141).
  • Mutation; HGNC; HGNC:76; ABL1; Simple; p.Glu470Lys (c.1408G>A); Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=21718141).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Arg (c.395A>G); ClinVar=VCV000376625; Zygosity=Homozygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0379 (Ku812)
Sex of cell Male
Age at sampling 38Y
Category Cancer cell line
Publications

PubMed=21718141; DOI=10.3109/10428194.2011.591013
Tang C., Schafranek L., Watkins D.B., Parker W.T., Moore S., Prime J.A., White D.L., Hughes T.P.
Tyrosine kinase inhibitor resistance in chronic myeloid leukemia cell lines: investigating resistance pathways.
Leuk. Lymphoma 52:2139-2147(2011)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1