Cellosaurus logo
expasy logo

Cellosaurus K562 Dox IM1 (CVCL_E6I0)

[Text version]
Cell line name K562 Dox IM1
Synonyms K562 Dox 2microM IM1
Accession CVCL_E6I0
Resource Identification Initiative To cite this cell line use: K562 Dox IM1 (RRID:CVCL_E6I0)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E6HY (K562 Dox)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=21718141; DOI=10.3109/10428194.2011.591013
Tang C., Schafranek L., Watkins D.B., Parker W.T., Moore S., Prime J.A., White D.L., Hughes T.P.
Tyrosine kinase inhibitor resistance in chronic myeloid leukemia cell lines: investigating resistance pathways.
Leuk. Lymphoma 52:2139-2147(2011)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1