Cellosaurus cell line K562 Dox (CVCL

Cellosaurus K562 Dox (CVCL_E6HY)

[Text version]

Cell line name

K562 Dox

Synonyms

K562-Dox; K562/DOX; K562/Dox

Accession

CVCL_E6HY

Resource Identification Initiative

To cite this cell line use: K562 Dox (RRID:CVCL_E6HY)

Comments

From: Ashman, Leonie K.; University of Newcastle; Adelaide; Australia.
Population: Caucasian.
Characteristics: Stably overexpresses ABCB1 (PubMed=21718141).
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).

Disease

Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0004 (K-562)
Children:

CVCL_E6HZ (K562 Dox DAS)	CVCL_E6I0 (K562 Dox IM1)	CVCL_E6I1 (K562 Dox IM2)
CVCL_E6I2 (K562 Dox IM3)	CVCL_E6IE (K562 Dox #5 NIL)	CVCL_E6IF (K562 Dox #8 NIL)

Sex of cell

Female

Age at sampling

53Y