| Cell line name |
SF295 MX50 |
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| Accession |
CVCL_E5T9 |
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| Resource Identification Initiative |
To cite this cell line use: SF295 MX50 (RRID:CVCL_E5T9) |
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| Comments |
Population: Caucasian.
Characteristics: Resistant to 50 nM of mitoxantrone (PubMed=15993268).
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: In situ; Brain, left temporal lobe; UBERON=UBERON_0002808. |
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| Sequence variations |
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
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| Disease |
Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1690 (SF295) |
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| Sex of cell |
Female |
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| Age at sampling |
67Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=12642696; DOI=10.4161/cbt.322
Yasumasa Honjo, Kuniaki Morisaki, Lyn Mickley Huff, Robert W. Robey, Jeffrey Hung, Michael Dean, Susan E. Bates;
Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1).
Cancer Biol. Ther. 1:696-702(2002) PubMed=15993268; DOI=10.1016/j.cancergencyto.2004.12.013
V. Koneti Rao, Darawalee Wangsa Zong, Robert W. Robey, Lyn Mickley Huff, Yasumasa Honjo, Jeffrey Hung, Turid Knutsen, Thomas Ried, Susan E. Bates;
Characterization of ABCG2 gene amplification manifesting as extrachromosomal DNA in mitoxantrone-selected SF295 human glioblastoma cells.
Cancer Genet. Cytogenet. 160:126-133(2005) |
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| Cross-references |
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| Cell line collections (Providers) |
ABM; T8038
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| Entry history |
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| Entry creation | 10-Apr-2025 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 1 |
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