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Cellosaurus SF295 MX50 (CVCL_E5T9)

[Text version]
Cell line name SF295 MX50
Accession CVCL_E5T9
Resource Identification Initiative To cite this cell line use: SF295 MX50 (RRID:CVCL_E5T9)
Comments Population: Caucasian.
Characteristics: Resistant to 50 nM of mitoxantrone (PubMed=15993268).
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: In situ; Brain, left temporal lobe; UBERON=UBERON_0002808.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1690 (SF295)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=12642696; DOI=10.4161/cbt.322
Honjo Y., Morisaki K., Huff L.M., Robey R.W., Hung J., Dean M., Bates S.E.
Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1).
Cancer Biol. Ther. 1:696-702(2002)

PubMed=15993268; DOI=10.1016/j.cancergencyto.2004.12.013
Rao V.K., Wangsa Zong D., Robey R.W., Huff L.M., Honjo Y., Hung J., Knutsen T., Ried T., Bates S.E.
Characterization of ABCG2 gene amplification manifesting as extrachromosomal DNA in mitoxantrone-selected SF295 human glioblastoma cells.
Cancer Genet. Cytogenet. 160:126-133(2005)

Cross-references
Cell line collections (Providers) ABM; T8038
Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1