ID   SF295 MX50
AC   CVCL_E5T9
DR   ABM; T8038
RX   PubMed=12642696;
RX   PubMed=15993268;
CC   Population: Caucasian.
CC   Characteristics: Resistant to 50 nM of mitoxantrone (PubMed=15993268).
CC   Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Brain, left temporal lobe; UBERON=UBERON_0002808.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1690 ! SF295
SX   Female
AG   67Y
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
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RX   PubMed=12642696; DOI=10.4161/cbt.322;
RA   Honjo Y., Morisaki K., Huff L.M., Robey R.W., Hung J., Dean M.,
RA   Bates S.E.;
RT   "Single-nucleotide polymorphism (SNP) analysis in the ABC
RT   half-transporter ABCG2 (MXR/BCRP/ABCP1).";
RL   Cancer Biol. Ther. 1:696-702(2002).
//
RX   PubMed=15993268; DOI=10.1016/j.cancergencyto.2004.12.013;
RA   Rao V.K., Wangsa Zong D., Robey R.W., Huff L.M., Honjo Y., Hung J.,
RA   Knutsen T., Ried T., Bates S.E.;
RT   "Characterization of ABCG2 gene amplification manifesting as
RT   extrachromosomal DNA in mitoxantrone-selected SF295 human
RT   glioblastoma cells.";
RL   Cancer Genet. Cytogenet. 160:126-133(2005).
//