| Cell line name |
MCF-7 FLV250 |
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| Synonyms |
MCF-7-FLV250 |
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| Accession |
CVCL_E5SY |
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| Resource Identification Initiative |
To cite this cell line use: MCF-7 FLV250 (RRID:CVCL_E5SY) |
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| Comments |
Population: Caucasian.
Characteristics: Resistant to 250 nM of flavopiridol (PubMed=11205902).
Selected for resistance to: ChEBI; CHEBI_47344; Alvocidib (Flavopiridol; HMR-1275).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0031 (MCF-7) |
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| Sex of cell |
Female |
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| Age at sampling |
69Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=11205902
Robert W. Robey, Wilma Y. Medina-Perez, Kenryu Nishiyama, Tyler Lahusen, Keisuke Miyake, Thomas Litman, Adrian M. Senderowicz, Douglas D. Ross, Susan E. Bates;
Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.
Clin. Cancer Res. 7:145-152(2001) PubMed=12642696; DOI=10.4161/cbt.322
Yasumasa Honjo, Kuniaki Morisaki, Lyn Mickley Huff, Robert W. Robey, Jeffrey Hung, Michael Dean, Susan E. Bates;
Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1).
Cancer Biol. Ther. 1:696-702(2002) |
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| Entry history |
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| Entry creation | 10-Apr-2025 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 1 |
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