ID   MCF-7 FLV250
AC   CVCL_E5SY
SY   MCF-7-FLV250
RX   PubMed=11205902;
RX   PubMed=12642696;
CC   Population: Caucasian.
CC   Characteristics: Resistant to 250 nM of flavopiridol (PubMed=11205902).
CC   Selected for resistance to: ChEBI; CHEBI_47344; Alvocidib (Flavopiridol; HMR-1275).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
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RX   PubMed=11205902;
RA   Robey R.W., Medina-Perez W.Y., Nishiyama K., Lahusen T., Miyake K.,
RA   Litman T., Senderowicz A.M., Ross D.D., Bates S.E.;
RT   "Overexpression of the ATP-binding cassette half-transporter, ABCG2
RT   (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer
RT   cells.";
RL   Clin. Cancer Res. 7:145-152(2001).
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RX   PubMed=12642696; DOI=10.4161/cbt.322;
RA   Honjo Y., Morisaki K., Huff L.M., Robey R.W., Hung J., Dean M.,
RA   Bates S.E.;
RT   "Single-nucleotide polymorphism (SNP) analysis in the ABC
RT   half-transporter ABCG2 (MXR/BCRP/ABCP1).";
RL   Cancer Biol. Ther. 1:696-702(2002).
//