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Cellosaurus NIH 3T3 hRRAS2 G24V (CVCL_E5LM)

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Cell line name NIH 3T3 hRRAS2 G24V
Accession CVCL_E5LM
Resource Identification Initiative To cite this cell line use: NIH 3T3 hRRAS2 G24V (RRID:CVCL_E5LM)
Comments Characteristics: Displays transforming activity in focus formation assays (PubMed=36476833).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:17271; RRAS2 (Note=With p.Gly24Val and a N-terminal HA tag).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Whole embryo; UBERON=UBERON_0000922.
Cell type: Fibroblast; CL=CL_0000057.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: NIH Swiss.
Hierarchy Parent: CVCL_0594 (NIH 3T3)
Sex of cell Male
Age at sampling Embryo
Category Spontaneously immortalized cell line
Publications

PubMed=36476833; DOI=10.1038/s41388-022-02563-9; PMCID=PMC9883167
Laura Clavain, Maria Isabel Fernandez-Pisonero, Nieves Movilla, Luis Francisco Lorenzo-Martin, Blanca Nieto, Antonio Abad, Rosula Garcia-Navas, Clara Llorente-Gonzalez, Manuel Sanchez-Martin, Miguel Vicente-Manzanares, Eugenio Santos ...Show all 15 authors... , Balbino Alarcon, Jose Manuel Garcia-Aznar, Mercedes Dosil, Xose R. Bustelo; Show fewer authors
Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors.
Oncogene 42:389-405(2023)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2