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Cellosaurus RPMI-8226-B25 (CVCL_E5J8)

[Text version]
Cell line name RPMI-8226-B25
Synonyms 8226/B25; 8226-B25
Accession CVCL_E5J8
Resource Identification Initiative To cite this cell line use: RPMI-8226-B25 (RRID:CVCL_E5J8)
Comments Population: African American.
Characteristics: Resistant to 25 nM of bortezomib (DOI=10.1182/blood.V124.21.2084.2084).
Characteristics: Produces IgG lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI_52717; Bortezomib (Velcade).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; HGNC:5722; IGKJ4 + HGNC; HGNC:5783; IGKV2-28; Name(s)=IGKV2-28-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; HGNC:5865; IGLJ3 + HGNC; HGNC:5888; IGLV2-14; Name(s)=IGLV2-14-IGLJ3 (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0014 (RPMI-8226)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
Publications

DOI=10.1182/blood.V124.21.2084.2084
Turner J.G., Dawson J.L., Grant S., Shain K.H., Dai Y., Cubitt C.L., Baz R.C., Nishihori T., Kauffman M.G., Shacham S., Sullivan D.M.
Melphalan and XPO1 inhibitor combination therapy for the treatment of multiple myeloma.
Blood 124 Suppl. 1:2084-2084(2014)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1