| Cell line name |
RPMI-8226-B25 |
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| Synonyms |
8226/B25; 8226-B25 |
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| Accession |
CVCL_E5J8 |
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| Resource Identification Initiative |
To cite this cell line use: RPMI-8226-B25 (RRID:CVCL_E5J8) |
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| Comments |
Population: African American.
Characteristics: Resistant to 25 nM of bortezomib (DOI=10.1182/blood.V124.21.2084.2084).
Characteristics: Produces IgG lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI_52717; Bortezomib (Velcade).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786. |
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| Sequence variations |
- Gene fusion; HGNC; HGNC:5722; IGKJ4 + HGNC; HGNC:5783; IGKV2-28; Name(s)=IGKV2-28-IGKJ4 (from parent cell line).
- Gene fusion; HGNC; HGNC:5865; IGLJ3 + HGNC; HGNC:5888; IGLV2-14; Name(s)=IGLV2-14-IGLJ3 (from parent cell line).
- Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line).
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| Disease |
Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0014 (RPMI-8226) |
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| Sex of cell |
Male |
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| Age at sampling |
61Y |
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| Category |
Cancer cell line |
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| Publications | DOI=10.1182/blood.V124.21.2084.2084
Joel G. Turner, Jana L. Dawson, Steven Grant, Kenneth H. Shain, Yun Dai, Christopher L. Cubitt, Rachid Chafic Baz, Taiga Nishihori, Michael G. Kauffman, Sharon Shacham, Daniel M. Sullivan;
Melphalan and XPO1 inhibitor combination therapy for the treatment of multiple myeloma.
Blood 124 Suppl. 1:2084-2084(2014) |
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| Entry history |
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| Entry creation | 10-Apr-2025 |
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| Last entry update | 14-Aug-2025 |
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| Version number | 2 |
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