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Cellosaurus RPMI-8226/Dox (CVCL_E5J7)

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Cell line name RPMI-8226/Dox
Synonyms 8226/Dox
Accession CVCL_E5J7
Resource Identification Initiative To cite this cell line use: RPMI-8226/Dox (RRID:CVCL_E5J7)
Comments Population: African American.
Characteristics: Resistant to 1 x 10-7 M of doxorubicin (PubMed=2875788).
Characteristics: Produces IgG lambda (from parent cell line).
Doubling time: 28.9 hours (PubMed=2875788).
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Gene fusion; HGNC; HGNC:5722; IGKJ4 + HGNC; HGNC:5783; IGKV2-28; Name(s)=IGKV2-28-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; HGNC:5865; IGLJ3 + HGNC; HGNC:5888; IGLV2-14; Name(s)=IGLV2-14-IGLJ3 (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0014 (RPMI-8226)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
Publications

PubMed=2875788
William S. Dalton, Brian G.M. Durie, David Samuel Alberts, James H. Gerlach, Anne Elizabeth Cress;
Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein.
Cancer Res. 46:5125-5130(1986)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2