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Cellosaurus NF1-08-CL (CVCL_E5GK)

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Cell line name NF1-08-CL
Synonyms MPNST-NF1-08-CL
Accession CVCL_E5GK
Resource Identification Initiative To cite this cell line use: NF1-08-CL (RRID:CVCL_E5GK)
Comments Population: Caucasian; Spanish.
Doubling time: 2.90 days (PubMed=37798904).
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Dorsal nerve of penis; UBERON=UBERON_0019197.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=37798904).
  • Gene deletion; HGNC; HGNC:7765; NF1; Zygosity=Heterozygous (PubMed=37798904).
  • Gene deletion; HGNC; HGNC:17101; SUZ12; Zygosity=Heterozygous (PubMed=37798904).
  • Mutation; HGNC; HGNC:7765; NF1; Simple; c.701_730+10del; Zygosity=Heterozygous; Note=Germline (PubMed=37798904).
  • Mutation; HGNC; HGNC:17101; SUZ12; Simple; p.Glu415Glyfs*5 (c.1236_1240del); Zygosity=Heterozygous (PubMed=37798904).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line
Publications

PubMed=37798904; DOI=10.1002/1878-0261.13534; PMCID=PMC10994238
Edgar Creus-Bachiller, Juana Fernandez-Rodriguez, Miriam Magallon-Lorenz, Sara Ortega-Bertran, Susana Navas-Rutete, Cleofe Romagosa, Tulio M. Silva, Maria Pane Foix, Anna Estival, Diana Perez Sidelnikova, Mireia Morell Ginesta ...Show all 19 authors... , Helena Mazuelas, Meritxell Carrio, Tereza Lausova, David E. Reuss, Bernat Gel, Alberto Villanueva, Eduard Serra, Conxi Lazaro; Show fewer authors
Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: new patient-derived orthotopic xenografts, cell lines and tumor entities.
Mol. Oncol. 18:895-917(2024)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1