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Cellosaurus NF1-08-CL (CVCL_E5GK)

[Text version]
Cell line name NF1-08-CL
Synonyms MPNST-NF1-08-CL
Accession CVCL_E5GK
Resource Identification Initiative To cite this cell line use: NF1-08-CL (RRID:CVCL_E5GK)
Comments Population: Caucasian; Spanish.
Doubling time: 2.90 days (PubMed=37798904).
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Dorsal nerve of penis; UBERON=UBERON_0019197.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=37798904).
  • Gene deletion; HGNC; HGNC:7765; NF1; Zygosity=Heterozygous (PubMed=37798904).
  • Gene deletion; HGNC; HGNC:17101; SUZ12; Zygosity=Heterozygous (PubMed=37798904).
  • Mutation; HGNC; HGNC:7765; NF1; Simple; c.701_730+10del; Zygosity=Heterozygous; Note=Germline (PubMed=37798904).
  • Mutation; HGNC; HGNC:17101; SUZ12; Simple; p.Glu415Glyfs*5 (c.1236_1240del); Zygosity=Heterozygous (PubMed=37798904).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line
Publications

PubMed=37798904; DOI=10.1002/1878-0261.13534; PMCID=PMC10994238
Creus-Bachiller E., Fernandez-Rodriguez J., Magallon-Lorenz M., Ortega-Bertran S., Navas-Rutete S., Romagosa C., Silva T.M., Pane Foix M., Estival A., Perez Sidelnikova D., Morell Ginesta M., Mazuelas H., Carrio M., Lausova T., Reuss D.E., Gel B., Villanueva A., Serra E., Lazaro C.
Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: new patient-derived orthotopic xenografts, cell lines and tumor entities.
Mol. Oncol. 18:895-917(2024)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1