ID   NF1-08-CL
AC   CVCL_E5GK
SY   MPNST-NF1-08-CL
RX   PubMed=37798904;
CC   Population: Caucasian; Spanish.
CC   Doubling time: 2.90 days (PubMed=37798904).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=37798904).
CC   Sequence variation: Gene deletion; HGNC; HGNC:7765; NF1; Zygosity=Heterozygous (PubMed=37798904).
CC   Sequence variation: Gene deletion; HGNC; HGNC:17101; SUZ12; Zygosity=Heterozygous (PubMed=37798904).
CC   Sequence variation: Mutation; HGNC; HGNC:7765; NF1; Simple; c.701_730+10del; Zygosity=Heterozygous; Note=Germline (PubMed=37798904).
CC   Sequence variation: Mutation; HGNC; HGNC:17101; SUZ12; Simple; p.Glu415Glyfs*5 (c.1236_1240del); Zygosity=Heterozygous (PubMed=37798904).
CC   Omics: Genomics; Whole exome sequencing.
CC   Derived from site: In situ; Dorsal nerve of penis; UBERON=UBERON_0019197.
DI   NCIt; C3798; Malignant peripheral nerve sheath tumor
DI   NCIt; C3273; Neurofibromatosis type 1
DI   ORDO; Orphanet_3148; Malignant peripheral nerve sheath tumor
DI   ORDO; Orphanet_636; Neurofibromatosis type 1
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   28Y
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
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RX   PubMed=37798904; DOI=10.1002/1878-0261.13534; PMCID=PMC10994238;
RA   Creus-Bachiller E., Fernandez-Rodriguez J., Magallon-Lorenz M.,
RA   Ortega-Bertran S., Navas-Rutete S., Romagosa C., Silva T.M.,
RA   Pane Foix M., Estival A., Perez Sidelnikova D., Morell Ginesta M.,
RA   Mazuelas H., Carrio M., Lausova T., Reuss D.E., Gel B., Villanueva A.,
RA   Serra E., Lazaro C.;
RT   "Expanding a precision medicine platform for malignant peripheral
RT   nerve sheath tumors: new patient-derived orthotopic xenografts, cell
RT   lines and tumor entities.";
RL   Mol. Oncol. 18:895-917(2024).
//