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Cellosaurus IVR01 (CVCL_E5FT)

[Text version]
Cell line name IVR01
Synonyms In Vivo Resistant 01
Accession CVCL_E5FT
Resource Identification Initiative To cite this cell line use: IVR01 (RRID:CVCL_E5FT)
Comments Population: Caucasian.
Characteristics: Female nude mice were injected IP with the parent cell line. Once tumours were established the mice were treated with carboplatin. This cell line was establishe from one of these in-vivo established resistant tumor cells (PubMed=35918200).
Selected for resistance to: ChEBI; CHEBI_31355; Carboplatin (CBP; Paraplatin).
Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Misspelling: IVRO1; CancerTools=161758.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu130Val (c.388C>G); ClinVar=VCV000458543; Zygosity=Homozygous (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E5FK (OVCAR4-Luc)
Sex of cell Female
Age at sampling 42Y
Category Cancer cell line
Publications

PubMed=35918200; DOI=10.1016/j.ygyno.2022.07.027
Hoare J.I., Hockings H., Saxena J., Silva V.L., Haughey M.J., Wood G.E., Nicolini F., Mirza H., McNeish I.A., Huang W.-N., Maniati E., Graham T.A., Lockley M.
A novel cell line panel reveals non-genetic mediators of platinum resistance and phenotypic diversity in high grade serous ovarian cancer.
Gynecol. Oncol. 167:96-106(2022)

Cross-references
Cell line collections (Providers) CancerTools; 161758
Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1