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Cellosaurus OVCAR4-Luc (CVCL_E5FK)

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Cell line name OVCAR4-Luc
Accession CVCL_E5FK
Resource Identification Initiative To cite this cell line use: OVCAR4-Luc (RRID:CVCL_E5FK)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu130Val (c.388C>G); ClinVar=VCV000458543; Zygosity=Homozygous (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1627 (OVCAR-4)
Children:
CVCL_E5FT (IVR01)CVCL_E5FU (IVR02)
Sex of cell Female
Age at sampling 42Y
Category Cancer cell line
Publications

PubMed=35918200; DOI=10.1016/j.ygyno.2022.07.027
Joseph I. Hoare, Helen Hockings, Jayeta Saxena, Vera L. Silva, Magnus J. Haughey, Georgina Elizabeth Wood, Francesco Nicolini, Hasan Mirza, Iain Alexander McNeish, Wei-Ni Huang, Eleni Maniati ...Show all 13 authors... , Trevor A. Graham, Michelle Lockley; Show fewer authors
A novel cell line panel reveals non-genetic mediators of platinum resistance and phenotypic diversity in high grade serous ovarian cancer.
Gynecol. Oncol. 167:96-106(2022)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2