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Cellosaurus U2OS E2F7 KO (CVCL_E5FF)

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Cell line name U2OS E2F7 KO
Accession CVCL_E5FF
Resource Identification Initiative To cite this cell line use: U2OS E2F7 KO (RRID:CVCL_E5FF)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:23820; E2F7.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=29590434; DOI=10.1093/nar/gky218; PMCID=PMC5961008
Jone Mitxelena, Aintzane Apraiz, Jon Vallejo-Rodriguez, Iraia Garcia-Santisteban, Asier Fullaondo, Monica Alvarez-Fernandez, Marcos Malumbres, Ana Maria Zubiaga Elordieta;
An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability.
Nucleic Acids Res. 46:4546-4559(2018)

Cross-references
Cell line collections (Providers) CancerTools; 156469
Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1