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Cellosaurus A431 GR (CVCL_E4DP)

[Text version]
Cell line name A431 GR
Synonyms A431-GR; A431_GR
Accession CVCL_E4DP
Resource Identification Initiative To cite this cell line use: A431 GR (RRID:CVCL_E4DP)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Sequence variations
  • Gene fusion; HGNC; HGNC:3236; EGFR + HGNC; HGNC:9237; PPARGC1A; Name(s)=EGFR-PPARGC1A (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0037 (A-431)
Sex of cell Female
Age at sampling 85Y
Category Cancer cell line
Publications

PubMed=18568074; DOI=10.1172/JCI34588; PMCID=PMC2430495
Marta Guix, Anthony C. Faber, Shi-Zhen Emily Wang, Maria Graciela Olivares, Youngchul Song, Sherman Qu, Cammie Rinehart, Brenda Seidel, Douglas Yee, Carlos L. Arteaga, Jeffrey Adam Engelman;
Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins.
J. Clin. Invest. 118:2609-2619(2008)

Cross-references
Gene expression databases GEO; GSM270527
GEO; GSM270528
GEO; GSM270529
Entry history
Entry creation19-Dec-2024
Last entry update10-Apr-2025
Version number2