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Cellosaurus MGH121 Res#1 (CVCL_E4DN)

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Cell line name MGH121 Res#1
Synonyms MGH121 Res # 1
Accession CVCL_E4DN
Resource Identification Initiative To cite this cell line use: MGH121 Res#1 (RRID:CVCL_E4DN)
Comments Selected for resistance to: ChEBI; CHEBI_61400; WZ4002 (N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (PubMed=25964297).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Cys797Ser (c.2389T>A); ClinVar=VCV000376342; Zygosity=Heterozygous; Note=Responsible for resistance to WZ4002. Located in the same allele as the p.Thr790Met mutation (PubMed=25964297).
  • Mutation; HGNC; HGNC:3236; EGFR; Unexplicit; Ex19del; Zygosity=Unspecified (from parent cell line).
Disease Lung non-small cell carcinoma (NCIt: C2926)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_DH49 (MGH121)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=25964297; DOI=10.1158/1078-0432.CCR-15-0560; PMCID=PMC4587765
Matthew J. Niederst, Hai-Chuan Hu, Hillary E. Mulvey, Elizabeth L. Lockerman, Angel R. Garcia, Zofia Piotrowska, Lecia VanDam Sequist, Jeffrey Adam Engelman;
The allelic context of the C797S mutation acquired upon treatment with third-generation EGFR inhibitors impacts sensitivity to subsequent treatment strategies.
Clin. Cancer Res. 21:3924-3933(2015)

Entry history
Entry creation19-Dec-2024
Last entry update10-Apr-2025
Version number2