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Cellosaurus NCI-N592/IL2/IFN-gamma (CVCL_E4CU)

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Cell line name NCI-N592/IL2/IFN-gamma
Synonyms N592/IL2/IFN-gamma
Accession CVCL_E4CU
Resource Identification Initiative To cite this cell line use: NCI-N592/IL2/IFN-gamma (RRID:CVCL_E4CU)
Comments Problematic cell line: Contaminated. Grand-parent cell line (NCI-N592) shown to be a NCI-H69 derivative.
Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:5438; IFNG.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6001; IL2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E4CT (NCI-N592/IL2)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
Publications

PubMed=9415308; DOI=10.1038/sj.gt.3300489
Catia Traversari, Raffaella Meazza, M. Coppolecchia, Stefania Basso, Alessandro Verrecchia, Pierre van der Bruggen, Andrea Ardizzoni, Aldo Gaggero, Silvano Ferrini;
IFN-gamma gene transfer restores HLA-class I expression and MAGE-3 antigen presentation to CTL in HLA-deficient small cell lung cancer.
Gene Ther. 4:1029-1035(1997)

Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number3