Cellosaurus cell line NCI-N592/IL2 (CVCL

Cellosaurus NCI-N592/IL2 (CVCL_E4CT)

[Text][XML][JSON]

Cell line name

NCI-N592/IL2

Synonyms

N592/IL2

Accession

CVCL_E4CT

Resource Identification Initiative

To cite this cell line use: NCI-N592/IL2 (RRID:CVCL_E4CT)

Comments

Problematic cell line: Contaminated. Parent cell line (NCI-N592) shown to be a NCI-H69 derivative.
Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6001; IL2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).

Disease

Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_A590 (NCI-N592)
Children:

CVCL_E4CU (NCI-N592/IL2/IFN-gamma)

Sex of cell

Male

Age at sampling

55Y