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Cellosaurus Hepa-1a (CVCL_E4AL)

[Text version]
Cell line name Hepa-1a
Synonyms Hepa 1a
Accession CVCL_E4AL
Resource Identification Initiative To cite this cell line use: Hepa-1a (RRID:CVCL_E4AL)
Comments Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Hepatocellular carcinoma of the mouse (NCIt: C38756)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57L/J.
Hierarchy Children:
CVCL_E4AR (Hepa-1a 1/c/1)CVCL_E4AS (Hepa-1a 19/2)CVCL_E4AM (Hepa-1aV1)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=4367319; DOI=10.1126/science.185.4154.859
Gretchen J. Darlington, Hans Peter Bernhard, Francis Hugh Ruddle;
Human serum albumin phenotype activation in mouse hepatoma-human leukocyte cell hybrids.
Science 185:859-862(1974)

PubMed=7005077; DOI=10.1007/BF02619329
David W. Sammons, E. Sanchez, Gretchen J. Darlington;
Immuno-overlay: a method for identification of hepatoma cell colonies that secrete albumin.
In Vitro 16:918-924(1980)

PubMed=6181572; DOI=10.1007/BF01538707
Gretchen J. Darlington, John Papaconstantinou, David W. Sammons, Peter C. Brown, Edith Y. Wong, Abbie L. Esterman, John Kang;
Generation and chracterization of variants of mouse hepatoma cells with defects in hepato-specific gene expression. I. Albumin synthesis variants.
Somatic Cell Genet. 8:451-464(1982)

PubMed=3431441; DOI=10.1016/s0076-6879(87)51006-0
Gretchen J. Darlington;
Liver cell lines.
Methods Enzymol. 151:19-38(1987)

Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number2