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Cellosaurus 1BR3-hTERT PBRM1 KO 5 + EV (CVCL_E3WF)

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Cell line name 1BR3-hTERT PBRM1 KO 5 + EV
Synonyms 1BR3 PBRM1 KO5 + EV
Accession CVCL_E3WF
Resource Identification Initiative To cite this cell line use: 1BR3-hTERT PBRM1 KO 5 + EV (RRID:CVCL_E3WF)
Comments Characteristics: Transduced with an empty TRIPz-neo construct. Control cell line for 1BR3-hTERT PBRM1 KO 5 + PBRM1 (Cellosaurus=CVCL_E3WE) (PubMed=35902118).
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:30064; PBRM1.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11730; TERT.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E3VD (1BR3-hTERT PBRM1 KO 5)
Sex of cell Male
Age at sampling 23Y
Category Telomerase immortalized cell line
Publications

PubMed=35902118; DOI=10.1101/gad.349249.121; PMCID=PMC9480851
Feng H.-G., Lane K.A., Roumeliotis T.I., Jeggo P.A., Somaiah N., Choudhary J.S., Downs J.A.
PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance.
Genes Dev. 36:790-806(2022)

Cross-references
Cell line collections (Providers) CancerTools; 161871
Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1