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Cellosaurus Ba/F3 EGFR-L718V/T790M/L858R (CVCL_E3MH)

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Cell line name Ba/F3 EGFR-L718V/T790M/L858R
Synonyms Ba/F3 EGFR-L858R/T790M/L718V
Accession CVCL_E3MH
Resource Identification Initiative To cite this cell line use: Ba/F3 EGFR-L718V/T790M/L858R (RRID:CVCL_E3MH)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3236; EGFR (Note=With p.Leu718Val (c.2152C>G), p.Thr790Met (c.2369C>T) and p.Leu858Arg (c.2573T>G)).
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Caution: The parent cell line was originally thought to originate from a BALB/c mouse but is in fact from a C3H mouse.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Pro-B cell; CL=CL_0000826.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3H.
Hierarchy Parent: CVCL_0161 (Ba/F3)
Category Factor-dependent cell line
Publications

PubMed=34526717; DOI=10.1038/s41586-021-03898-1; PMCID=PMC8481125
Jacqulyne P. Robichaux, Xiu-Ning Le, Ramaswamy S.K. Vijayan, James Kevin Hicks, Simon Heeke, Yasir Yousif Elamin, Heather Y. Lin, Hibiki Udagawa, Ferdinandos Skoulidis, Hai Tran, Susan Varghese ...Show all 33 authors... , Jun-Qin He, Fa-Hao Zhang, Monique B. Nilsson, Li-Mei Hu, Alissa Poteete, Waree Rinsurongkawong, Xiao-Shan Zhang, Cheng-Hui Ren, Xiao-Ke Liu, Ling-Zhi Hong, Jian-Jun Zhang, Li-Xia Diao, Russell William Madison, Alexa B. Schrock, Jennifer Saam, Victoria M. Raymond, Bing-Liang Fang, Jing Wang, Min Jin Ha, Jason B. Cross, Jhannelle E. Gray, John Victor Heymach; Show fewer authors
Structure-based classification predicts drug response in EGFR-mutant NSCLC.
Nature 597:732-737(2021)

Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number3