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Cellosaurus HepG2-FVII (CVCL_E3FN)

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Cell line name HepG2-FVII
Synonyms FVII-HepG2
Accession CVCL_E3FN
Resource Identification Initiative To cite this cell line use: HepG2-FVII (RRID:CVCL_E3FN)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3544; F7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=31381603; DOI=10.1371/journal.pone.0220825; PMCID=PMC6681952
Sarai Pongjantarasatian, Praguywan Kadegasem, Werasak Sasanakul, Khanit Sa-ngiamsuntorn, Suparerk Borwornpinyo, Nongnuch Sirachainan, Ampaiwan Chuansumrit, Pansakorn Tanratana, Suradej Hongeng;
Coagulant activity of recombinant human factor VII produced by lentiviral human F7 gene transfer in immortalized hepatocyte-like cell line.
PLoS ONE 14:e0220825.1-e0220825.12(2019)

Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number2