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Cellosaurus HGL5-MXIV (CVCL_E3DF)

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Cell line name HGL5-MXIV
Accession CVCL_E3DF
Resource Identification Initiative To cite this cell line use: HGL5-MXIV (RRID:CVCL_E3DF)
Comments Characteristics: Control cell line for HGL5-YAP(S127A) (Cellosaurus=CVCL_E3DG). Transduced with an empty vector (PubMed=34888112).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Donor information: Established from an IVF patient undergoing oocyte retrieval procedure (from parent cell line).
Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.
Cell type: Granulosa cell; CL=CL_0000501.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6644 (HGL5)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=34888112; DOI=10.1016/j.scib.2020.03.040; PMCID=PMC8654108
Xiang-Min Lv, Chun-Bo He, Cong Huang, Guo-Hua Hua, Xing-Cheng Chen, Barbara K. Timm, Victoria M. Maclin, Abigail A. Haggerty, Shelly K. Aust, Denae M. Golden, Bhavana J. Dave ...Show all 22 authors... , Yun-An Tseng, Li Chen, Hong-Bo Wang, Pei-Chao Chen, David L. Klinkebiel, Adam R. Karpf, Ji-Xin Dong, Ronny I. Drapkin, Bo R. Rueda, John S. Davis, Cheng Wang; Show fewer authors
Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features.
Sci. Bull. 65:1281-1296(2020)

Entry history
Entry creation10-Sep-2024
Last entry update14-Aug-2025
Version number3