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Cellosaurus HGL5 (CVCL_6644)

[Text version]
Cell line name HGL5
Synonyms HGL-5
Accession CVCL_6644
Resource Identification Initiative To cite this cell line use: HGL5 (RRID:CVCL_6644)
Comments Doubling time: 96 hours (Note=At 75th passage) (PubMed=8126145).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Donor information: Established from an IVF patient undergoing oocyte retrieval procedure (PubMed=8126145).
Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.
Cell type: Granulosa cell; CL=CL_0000501.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E3DF (HGL5-MXIV)CVCL_E3DG (HGL5-YAP(S127A))
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=8126145; DOI=10.1210/jcem.78.3.8126145
William E. Rainey, Chiravudh Sawetawan, Jerry W. Shay, M. Dodson Michael, J. Michael Mathis, William Hanna Kutteh, William Byrd, Bruce R. Carr;
Transformation of human granulosa cells with the E6 and E7 regions of human papillomavirus.
J. Clin. Endocrinol. Metab. 78:705-710(1994)

PubMed=15541573; DOI=10.1016/j.mce.2004.04.018
Jon Christopher Havelock, William E. Rainey, Bruce R. Carr;
Ovarian granulosa cell lines.
Mol. Cell. Endocrinol. 228:67-78(2004)

PubMed=22949596
Genovefa Bouraki, Chryssa Metallinou, Mara Simopoulou, Konstantinos Charalabopoulos, Byron Asimakopoulos;
Comparison of nine media in the culture of human ovarian granulosa lutein cells.
In Vivo 26:823-825(2012)

PubMed=34888112; DOI=10.1016/j.scib.2020.03.040; PMCID=PMC8654108
Xiang-Min Lv, Chun-Bo He, Cong Huang, Guo-Hua Hua, Xing-Cheng Chen, Barbara K. Timm, Victoria M. Maclin, Abigail A. Haggerty, Shelly K. Aust, Denae M. Golden, Bhavana J. Dave ...Show all 22 authors... , Yun-An Tseng, Li Chen, Hong-Bo Wang, Pei-Chao Chen, David L. Klinkebiel, Adam R. Karpf, Ji-Xin Dong, Ronny I. Drapkin, Bo R. Rueda, John S. Davis, Cheng Wang; Show fewer authors
Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features.
Sci. Bull. 65:1281-1296(2020)

Cross-references
Cell line collections (Providers) ABM; T0650
Encyclopedic resources Wikidata; Q54887287
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number15