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Cellosaurus H9/R7hyg (CVCL_E3D8)

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Cell line name H9/R7hyg
Accession CVCL_E3D8
Resource Identification Initiative To cite this cell line use: H9/R7hyg (RRID:CVCL_E3D8)
Comments Population: Caucasian.
Characteristics: Transfected with plasmid R7hyg containing a human immunodeficiency virus 1 (HIV-1) isolate HXB2 proviral clone containing HygR in place of the HIV-1 nef gene (PubMed=7523570).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene deletion; HGNC; HGNC:7208; MPDZ; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Homozygous (from parent cell line).
Disease Sezary syndrome (NCIt: C3366)
Sezary syndrome (ORDO: Orphanet_3162)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1240 (H9)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=7523570; DOI=10.1084/jem.180.4.1283; PMCID=PMC2191672
Theodore J. Tsomides, Anna Aldovini, R. Paul Johnson, Bruce D. Walker, Richard Allen Young, Herman Nathaniel Eisen;
Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.
J. Exp. Med. 180:1283-1293(1994)

Entry history
Entry creation10-Sep-2024
Last entry update19-Dec-2024
Version number2