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Cellosaurus OVCAR-5 CBPR (CVCL_E3AR)

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Cell line name OVCAR-5 CBPR
Accession CVCL_E3AR
Resource Identification Initiative To cite this cell line use: OVCAR-5 CBPR (RRID:CVCL_E3AR)
Comments Problematic cell line: Possibly misclassified. Parent cell line (OVCAR-5) was originally thought to be a high grade ovarian serous adenocarcinoma but suspected to have a upper gastrointestinal origin.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_31355; Carboplatin (CBP; Paraplatin).
Omics: Metabolomics.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1628 (OVCAR-5)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=35681748; DOI=10.3390/cancers14112763; PMCID=PMC9179525
Mitchell Acland, Noor A. Lokman, Clifford Young, Dovile Anderson, Mark Rocco Condina, Chris Desire, Tannith M. Noye, Wan-Qi Wang, Carmela Ricciardelli, Darren J. Creek, Martin K. Oehler ...Show all 13 authors... , Peter Hoffmann, Manuela Klingler-Hoffmann; Show fewer authors
Chemoresistant cancer cell lines are characterized by migratory, amino acid metabolism, protein catabolism and IFN1 signalling perturbations.
Cancers (Basel) 14:2763.1-2763.24(2022)

Entry history
Entry creation10-Sep-2024
Last entry update10-Apr-2025
Version number3