ID   OVCAR-5 CBPR
AC   CVCL_E3AR
RX   PubMed=35681748;
CC   Problematic cell line: Possibly misclassified. Parent cell line (OVCAR-5) was originally thought to be a high grade ovarian serous adenocarcinoma but suspected to have a upper gastrointestinal origin.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_31355; Carboplatin (CBP; Paraplatin).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
CC   Omics: Metabolomics.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C105555; High grade ovarian serous adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1628 ! OVCAR-5
SX   Female
AG   67Y
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 10-04-25; Version: 3
//
RX   PubMed=35681748; DOI=10.3390/cancers14112763; PMCID=PMC9179525;
RA   Acland, Mitchell
RA   Lokman, Noor A.
RA   Young, Clifford
RA   Anderson, Dovile
RA   Condina, Mark Rocco
RA   Desire, Chris
RA   Noye, Tannith M.
RA   Wang, Wan-Qi
RA   Ricciardelli, Carmela
RA   Creek, Darren J.
RA   Oehler, Martin K.
RA   Hoffmann, Peter
RA   Klingler-Hoffmann, Manuela
RT   "Chemoresistant cancer cell lines are characterized by migratory,
RT   amino acid metabolism, protein catabolism and IFN1 signalling
RT   perturbations.";
RL   Cancers (Basel) 14:2763.1-2763.24(2022).
//