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Cellosaurus Hs294T R (CVCL_E3AI)

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Cell line name Hs294T R
Accession CVCL_E3AI
Resource Identification Initiative To cite this cell line use: Hs294T R (RRID:CVCL_E3AI)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_90851; Cobimetinib (Cotellic).
Selected for resistance to: ChEBI; CHEBI_63637; Vemurafenib (Zelboraf; PLX4032).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0331 (Hs 294T)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
Publications

PubMed=39175042; DOI=10.1186/s12964-024-01788-3; PMCID=PMC11342534
Magdalena Kot, Aleksandra Simiczyjew, Justyna Wadzynska, Marcin Zietek, Rafa Adam Matkowski, Dorota Nowak;
Characterization of two melanoma cell lines resistant to BRAF/MEK inhibitors (vemurafenib and cobimetinib).
Cell Commun. Signal. 22:410.1-410.21(2024)

Entry history
Entry creation10-Sep-2024
Last entry update19-Dec-2024
Version number2