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Cellosaurus F20T (CVCL_E2X3)

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Cell line name F20T
Accession CVCL_E2X3
Resource Identification Initiative To cite this cell line use: F20T (RRID:CVCL_E2X3)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Donor information: Established from a patient undergoing corneal transplant surgery (PubMed=33157036).
Derived from site: In situ; Eye, cornea, endothelium; UBERON=UBERON_0001985.
Cell type: Endothelial cell of cornea; CL=CL_0000132.
Disease Fuchs endothelial dystrophy (NCIt: C84721)
Fuchs endothelial corneal dystrophy (ORDO: Orphanet_98974)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 54Y
Category Transformed cell line
Publications

PubMed=33157036; DOI=10.1016/j.chembiol.2020.10.007; PMCID=PMC7855261
Alicia J. Angelbello, Raphael Isaac Benhamou, Suzanne G. Rzuczek, Shruti Choudhary, Zhen-Zhi Tang, Jonathan L. Chen, Madhuparna Roy, Kye Won Wang, Ilyas Yildirim, Albert Suk Jun, Charles Allan Thornton, Matthew David Disney;
A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex.
Cell Chem. Biol. 28:34-45.e6(2021)

Entry history
Entry creation10-Sep-2024
Last entry update14-Aug-2025
Version number3