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Cellosaurus HCA2 [Human foreskin fibroblast] (CVCL_E2UW)

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Cell line name HCA2 [Human foreskin fibroblast]
Synonyms HCA 2
Accession CVCL_E2UW
Resource Identification Initiative To cite this cell line use: HCA2 [Human foreskin fibroblast] (RRID:CVCL_E2UW)
Comments Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
Cell type: Fibroblast of foreskin; CL=CL_1001608.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling <1M
Category Finite cell line
Publications

PubMed=7753810; DOI=10.1073/pnas.92.10.4352; PMCID=PMC41942
Makoto Nakanishi, Guy R. Adami, Ryan S. Robetorye, Asao Noda, Susan F. Venable, Diana Dimitrov, Olivia M. Pereira-Smith, James R. Smith;
Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA.
Proc. Natl. Acad. Sci. U.S.A. 92:4352-4356(1995)

PubMed=9310070; DOI=10.1093/gerona/52a.5.b229
Ivica Rubelj, Susan F. Venable, John Lednicky, Janet S. Butel, Timothy Bilyeu, Gretchen J. Darlington, Ewa Surmacz, Judith Campisi, Olivia M. Pereira-Smith;
Loss of T-antigen sequences allows SV40-transformed human cells in crisis to acquire a senescent-like phenotype.
J. Gerontol., A, Biol. Sci. Med. Sci. 52:B229-B234(1997)

PubMed=36323784; DOI=10.1038/s41586-022-05388-4
Teh-Wei Wang, Yoshikazu Johmura, Narumi Suzuki, Satotaka Omori, Toshiro Migita, Kiyoshi Yamaguchi, Seira Hatakeyama, Satoshi Yamazaki, Eigo Shimizu, Seiya Imoto, Yoichi Furukawa ...Show all 13 authors... , Akihiko Yoshimura, Makoto Nakanishi; Show fewer authors
Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes.
Nature 611:358-364(2022)

Cross-references
Gene expression databases GEO; GSE198396
Entry history
Entry creation10-Sep-2024
Last entry update10-Apr-2025
Version number2