Cellosaurus cell line HyCyte MEG-01 hJAK2_p.V617F_c.1849G>T (CVCL

Cross-references
Cell line name	HyCyte MEG-01 hJAK2_p.V617F_c.1849G>T
Synonyms	hJAK2_p.V617F_c.1849G>T MEG-01
Accession	CVCL_E2Q6
Resource Identification Initiative	To cite this cell line use: HyCyte MEG-01 hJAK2_p.V617F_c.1849G>T (RRID:CVCL_E2Q6)
Comments	Population: Japanese. Doubling time: 24-48 hours (Hysigen=CGKO-M2166). Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations	Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line). Mutation; HGNC; HGNC:18318; ASXL1; Simple; p.Gly646Trpfs*12 (c.1934dupG); ClinVar=VCV000426927; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:6192; JAK2; Simple_edited; p.Val617Phe (c.1849G>T); ClinVar=VCV000014662; Zygosity=Homozygous; Note=By CRISPR/Cas9 (Hysigen=CGMU-M2166). Mutation; HGNC; HGNC:11998; TP53; Simple; p.His233del (c.697_699delCAC); Zygosity=Heterozygous (from parent cell line).
Disease	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110) Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0425 (MEG-01)
Sex of cell	Male
Age at sampling	55Y
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; CGMU-M2166
Entry history
Entry creation	10-Sep-2024
Last entry update	19-Dec-2024
Version number	2