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Cellosaurus A7 [Rat optic nerve astrocyte] (CVCL_E148)

[Text version]
Cell line name A7 [Rat optic nerve astrocyte]
Accession CVCL_E148
Resource Identification Initiative To cite this cell line use: A7 [Rat optic nerve astrocyte] (RRID:CVCL_E148)
Comments Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Central nervous system, optic nerve; UBERON=UBERON_0000941.
Cell type: Astrocyte; CL=CL_0000127.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Sprague Dawley; RS=RS_0000681.
Sex of cell Sex unspecified
Category Transformed cell line
Publications

PubMed=3053737; DOI=10.1083/jcb.107.5.1977; PMCID=PMC2115320
Herbert M. Geller, Monique Dubois-Dalcq;
Antigenic and functional characterization of a rat central nervous system-derived cell line immortalized by a retroviral vector.
J. Cell Biol. 107:1977-1986(1988)

PubMed=8076662; DOI=10.1006/exnr.1994.1127
Godwin S. Okoye, William J. Freed, Herbert M. Geller;
Short-term immunosuppression enhances the survival of intracerebral grafts of A7-immortalized glial cells.
Exp. Neurol. 128:191-201(1994)

PubMed=7583324; DOI=10.1016/0006-8993(95)00575-B
Juin Fok-Seang, Linda C. Smith-Thomas, Sally Meiners, Elizabeth Muir, Jian-Sheng Du, Elizabeth Housden, Alan R. Johnson, Andreas Faissner, Herbert M. Geller, Roger John Keynes, John H. Rogers, James W. Fawcett;
An analysis of astrocytic cell lines with different abilities to promote axon growth.
Brain Res. 689:207-223(1995)

PubMed=10516297; DOI=10.1523/JNEUROSCI.19-20-08778.1999; PMCID=PMC6782756
Penny S. Fidler, Katrin Schuette, Richard A. Asher, Alexandre Dobbertin, Suzanne R. Thornton, Yolanda Calle-Patino, Elizabeth Muir, Joel M. Levine, Herbert M. Geller, John H. Rogers, Andreas Faissner, James W. Fawcett;
Comparing astrocytic cell lines that are inhibitory or permissive for axon growth: the major axon-inhibitory proteoglycan is NG2.
J. Neurosci. 19:8778-8788(1999)

Cross-references
Encyclopedic resources Wikidata; Q54607185
Entry history
Entry creation22-Oct-2012
Last entry update14-Aug-2025
Version number17