Cellosaurus logo
expasy logo

Cellosaurus LP-9 (CVCL_E109)

[Text version]
Cell line name LP-9
Synonyms LP9; AG07086; AG07086A
Accession CVCL_E109
Resource Identification Initiative To cite this cell line use: LP-9 (RRID:CVCL_E109)
Comments Senescence: Senesces at ~50-60 PDL (PubMed=6192933; PubMed=10648628).
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Cell type: Mesothelial cell; CL=CL_0000077.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E108 (LP9/TERT-1)
Sex of cell Female
Age at sampling 26Y
Category Finite cell line
Web pages Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=6186388; DOI=10.1016/0092-8674(82)90324-5
Ying-Jye Wu, Leroy Monroe Parker, Neil E. Binder, Michael A. Beckett, John H. Sinard, C. Thomas Griffiths, James George Rheinwald;
The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia.
Cell 31:693-703(1982)

PubMed=6192933; DOI=10.1016/0092-8674(83)90155-1
Nancy D. Connell, James George Rheinwald;
Regulation of the cytoskeleton in mesothelial cells: reversible loss of keratin and increase in vimentin during rapid growth in culture.
Cell 34:245-253(1983)

PubMed=3130603
Ross A. Tubo, James George Rheinwald;
Normal human mesothelial cells and fibroblasts transfected with the EJras oncogene become EGF-independent, but are not malignantly transformed.
Oncogene Res. 1:407-421(1987)

CLPUB00597
National Institute on Aging
1994 catalog of cell lines. NIA Aging Cell Repository.
(In misc. document) Institute for Medical Research (Camden, N.J.); pp.1-351; National Institutes of Health; Bethesda; USA (1994)

PubMed=9382953; DOI=10.1089/hum.1997.8.16-1867
Jo-Ellen Murphy, James George Rheinwald;
Intraperitoneal injection of genetically modified, human mesothelial cells for systemic gene therapy.
Hum. Gene Ther. 8:1867-1879(1997)

PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304
Mark A. Dickson, William Chun Hahn, Yasushi Ino, Vincent Ronfard, Jenny Y. Wu, Robert Allan Weinberg, David Neil Louis, Frederick Pei Li, James George Rheinwald;
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Mol. Cell. Biol. 20:1436-1447(2000)

PubMed=19489101; DOI=10.1002/stem.64; PMCID=PMC2733375
Sally Dabelsteen, Paula Hercule, Patricia Barron, Meghan Rice, Gregory Dorsainville, James George Rheinwald;
Epithelial cells derived from human embryonic stem cells display p16INK4A senescence, hypermotility, and differentiation properties shared by many P63+ somatic cell types.
Stem Cells 27:1388-1399(2009)

Cross-references
Cell line collections (Providers) Coriell; AG07086
Cell line databases/resources CLO; CLO_0035653
Anatomy/cell type resources BTO; BTO_0006469
Encyclopedic resources Wikidata; Q54902913
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number17