ID   LP-9
AC   CVCL_E109
SY   LP9; AG07086; AG07086A
DR   BTO; BTO_0006469
DR   CLO; CLO_0035653
DR   Coriell; AG07086
DR   Wikidata; Q54902913
RX   CelloPub=CLPUB00597;
RX   PubMed=3130603;
RX   PubMed=6186388;
RX   PubMed=6192933;
RX   PubMed=9382953;
RX   PubMed=10648628;
RX   PubMed=19489101;
WW   Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
CC   Senescence: Senesces at ~50-60 PDL (PubMed=6192933; PubMed=10648628).
CC   Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
CC   Cell type: Mesothelial cell; CL=CL_0000077.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   26Y
CA   Finite cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 17
//
RX   CelloPub=CLPUB00597;
RG   National Institute on Aging;
RT   "1994 catalog of cell lines. NIA Aging Cell Repository.";
RL   (In misc. document) Institute for Medical Research (Camden, N.J.); pp.1-351; National Institutes of Health; Bethesda; USA (1994).
//
RX   PubMed=3130603;
RA   Tubo R.A., Rheinwald J.G.;
RT   "Normal human mesothelial cells and fibroblasts transfected with the
RT   EJras oncogene become EGF-independent, but are not malignantly
RT   transformed.";
RL   Oncogene Res. 1:407-421(1987).
//
RX   PubMed=6186388; DOI=10.1016/0092-8674(82)90324-5;
RA   Wu Y.-J., Parker L.M., Binder N.E., Beckett M.A., Sinard J.H.,
RA   Griffiths C.T., Rheinwald J.G.;
RT   "The mesothelial keratins: a new family of cytoskeletal proteins
RT   identified in cultured mesothelial cells and nonkeratinizing
RT   epithelia.";
RL   Cell 31:693-703(1982).
//
RX   PubMed=6192933; DOI=10.1016/0092-8674(83)90155-1;
RA   Connell N.D., Rheinwald J.G.;
RT   "Regulation of the cytoskeleton in mesothelial cells: reversible loss
RT   of keratin and increase in vimentin during rapid growth in culture.";
RL   Cell 34:245-253(1983).
//
RX   PubMed=9382953; DOI=10.1089/hum.1997.8.16-1867;
RA   Murphy J.-E., Rheinwald J.G.;
RT   "Intraperitoneal injection of genetically modified, human mesothelial
RT   cells for systemic gene therapy.";
RL   Hum. Gene Ther. 8:1867-1879(1997).
//
RX   PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304;
RA   Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A.,
RA   Louis D.N., Li F.P., Rheinwald J.G.;
RT   "Human keratinocytes that express hTERT and also bypass a
RT   p16(INK4a)-enforced mechanism that limits life span become immortal yet
RT   retain normal growth and differentiation characteristics.";
RL   Mol. Cell. Biol. 20:1436-1447(2000).
//
RX   PubMed=19489101; DOI=10.1002/stem.64; PMCID=PMC2733375;
RA   Dabelsteen S., Hercule P., Barron P., Rice M., Dorsainville G.,
RA   Rheinwald J.G.;
RT   "Epithelial cells derived from human embryonic stem cells display
RT   p16INK4A senescence, hypermotility, and differentiation properties
RT   shared by many P63+ somatic cell types.";
RL   Stem Cells 27:1388-1399(2009).
//