Cellosaurus logo
expasy logo

Cellosaurus W-V (CVCL_E079)

[Text version]
Cell line name W-V
Synonyms WV1
Accession CVCL_E079
Resource Identification Initiative To cite this cell line use: W-V (RRID:CVCL_E079)
Comments Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:12791; WRN; Simple; p.Lys924fs*973 (c.2773delG); Zygosity=Unspecified (PubMed=9230208).
Disease Werner syndrome (NCIt: C3447)
Werner syndrome (ORDO: Orphanet_902)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 45Y
Category Transformed cell line
STR profile Source(s): RCB=RCB0252

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81811,12
D7S8209,10
D13S3178,13
D16S5399
TH019
TPOX8
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=2878433; DOI=10.1098/rspb.1986.0070
Lily I. Huschtscha, K.V.A. Thompson, Robin Holliday;
The susceptibility of Werner's syndrome and other human skin fibroblasts to SV40-induced transformation and immortalization.
Proc. R. Soc. Lond. B. Biol. Sci. 229:1-12(1986)

PubMed=2762303; DOI=10.1073/pnas.86.15.5893; PMCID=PMC297737
Ken-ichiro Fukuchi, George M. Martin, Raymond J. Monnat Jr.;
Mutator phenotype of Werner syndrome is characterized by extensive deletions.
Proc. Natl. Acad. Sci. U.S.A. 86:5893-5897(1989)

PubMed=9230208
Samuel E. Bennett, Asad Umar, Junko Oshima, Raymond J. Monnat Jr., Thomas A. Kunkel;
Mismatch repair in extracts of Werner syndrome cell lines.
Cancer Res. 57:2956-2960(1997)

CLPUB00712
Jeremy David Henson;
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006); University of Sydney; Sydney; Australia

PubMed=19935656; DOI=10.1038/nbt.1587
Jeremy David Henson, Ying Cao, Lily I. Huschtscha, Andy C.-M. Chang, Amy Y.M. Au, Hilda A. Pickett, Roger Robert Reddel;
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

PubMed=22989712; DOI=10.1093/nar/gks862; PMCID=PMC3510502
Aaron Mendez-Bermudez, Alberto Hidalgo-Bravo, Victoria E. Cotton, Athanasia Gravani, Jennie N. Jeyapalan, Nicola Jane Royle;
The roles of WRN and BLM RecQ helicases in the alternative lengthening of telomeres.
Nucleic Acids Res. 40:10809-10820(2012)

Cross-references
Cell line collections (Providers) RCB; RCB0252
Cell line databases/resources CLO; CLO_0050644
Biological sample resources BioSample; SAMN03472349
Encyclopedic resources Wikidata; Q54993450
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number20