ID   W-V
AC   CVCL_E079
SY   WV1
DR   CLO; CLO_0050644
DR   BioSample; SAMN03472349
DR   RCB; RCB0252
DR   Wikidata; Q54993450
RX   CelloPub=CLPUB00712;
RX   PubMed=2762303;
RX   PubMed=2878433;
RX   PubMed=9230208;
RX   PubMed=19935656;
RX   PubMed=22989712;
CC   Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
CC   Sequence variation: Mutation; HGNC; 12791; WRN; Simple; p.Lys924fs*973 (c.2773delG); Zygosity=Unspecified (PubMed=9230208).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
ST   Source(s): RCB=RCB0252
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 8,13
ST   D16S539: 9
ST   D5S818: 11,12
ST   D7S820: 9,10
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 15,18
DI   NCIt; C3447; Werner syndrome
DI   ORDO; Orphanet_902; Werner syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   45Y
CA   Transformed cell line
DT   Created: 22-10-12; Last updated: 02-05-24; Version: 19
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RX   CelloPub=CLPUB00712;
RA   Henson J.D.;
RT   "The role of alternative lengthening of telomeres in human cancer.";
RL   Thesis PhD (2006), University of Sydney, Australia.
//
RX   PubMed=2762303; DOI=10.1073/pnas.86.15.5893;
RA   Fukuchi K.-i., Martin G.M., Monnat R.J. Jr.;
RT   "Mutator phenotype of Werner syndrome is characterized by extensive
RT   deletions.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:5893-5897(1989).
//
RX   PubMed=2878433; DOI=10.1098/rspb.1986.0070;
RA   Huschtscha L.I., Thompson K.V.A., Holliday R.;
RT   "The susceptibility of Werner's syndrome and other human skin
RT   fibroblasts to SV40-induced transformation and immortalization.";
RL   Proc. R. Soc. Lond. B. Biol. Sci. 229:1-12(1986).
//
RX   PubMed=9230208;
RA   Bennett S.E., Umar A., Oshima J., Monnat R.J. Jr., Kunkel T.A.;
RT   "Mismatch repair in extracts of Werner syndrome cell lines.";
RL   Cancer Res. 57:2956-2960(1997).
//
RX   PubMed=19935656; DOI=10.1038/nbt.1587;
RA   Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M.,
RA   Pickett H.A., Reddel R.R.;
RT   "DNA C-circles are specific and quantifiable markers of
RT   alternative-lengthening-of-telomeres activity.";
RL   Nat. Biotechnol. 27:1181-1185(2009).
//
RX   PubMed=22989712; DOI=10.1093/nar/gks862;
RA   Mendez-Bermudez A., Hidalgo-Bravo A., Cotton V.E., Gravani A.,
RA   Jeyapalan J.N., Royle N.J.;
RT   "The roles of WRN and BLM RecQ helicases in the alternative
RT   lengthening of telomeres.";
RL   Nucleic Acids Res. 40:10809-10820(2012).
//