Cellosaurus logo
expasy logo
Due to maintenance work, this service will be unavailable on Monday between 06:00 until 06:30 CEST. Apologies for the inconvenience.

Cellosaurus TEN (CVCL_E063)

[Text version]
Cell line name TEN
Accession CVCL_E063
Resource Identification Initiative To cite this cell line use: TEN (RRID:CVCL_E063)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Doubling time: 47.1 hours (Note=At 31th passage), 59.3 hours (Note=At 22th passage) (PubMed=9436040).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Thr74Pro (c.220A>C); ClinVar=VCV000929160; Zygosity=Heterozygous (DepMap=ACH-000397).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg342Ter (c.1024C>T); ClinVar=VCV000182970; Zygosity=Homozygous (DepMap=ACH-000397).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.21
Native American0
East Asian, North76.96
East Asian, South22.41
South Asian0.11
European, North0
European, South0.3
Disease Endometrial carcinoma (NCIt: C7558)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 74Y
Category Cancer cell line
STR profile Source(s): RCB=RCB1433

Markers:
AmelogeninX
CSF1PO10,12
D5S81811,12
D7S82010,12
D13S31710,12
D16S53911,12
TH017,8
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=9436040
Fushiki H., Hidaka T., Fujimura M., Yasoshima K., Yamakawa Y., Izumi R.
Characterization of a newly established human tumor cell line (TEN) from a patient with clear cell carcinoma of the uterine body and its sensitivity to anti-cancer agents.
Hum. Cell 10:199-208(1997)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) RCB; RCB1433
Cell line databases/resources CLO; CLO_0050884
cancercelllines; CVCL_E063
Cell_Model_Passport; SIDM01463
DepMap; ACH-000397
Biological sample resources BioSample; SAMN03472138
BioSample; SAMN10987928
CRISP screens repositories BioGRID_ORCS_Cell_line; 693
Chemistry resources PharmacoDB; TEN_1586_2019
Encyclopedic resources Wikidata; Q54972059
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887703
GEO; GSM888796
Polymorphism and mutation databases IARC_TP53; 28253
LiGeA; CCLE_209
Progenetix; CVCL_E063
Entry history
Entry creation22-Oct-2012
Last entry update02-May-2024
Version number24