ID   TEN
AC   CVCL_E063
DR   CLO; CLO_0050884
DR   ArrayExpress; E-MTAB-2770
DR   BioGRID_ORCS_Cell_line; 693
DR   BioSample; SAMN03472138
DR   BioSample; SAMN10987928
DR   cancercelllines; CVCL_E063
DR   Cell_Model_Passport; SIDM01463
DR   DepMap; ACH-000397
DR   GEO; GSM887703
DR   GEO; GSM888796
DR   IARC_TP53; 28253
DR   LiGeA; CCLE_209
DR   PharmacoDB; TEN_1586_2019
DR   Progenetix; CVCL_E063
DR   RCB; RCB1433
DR   Wikidata; Q54972059
RX   PubMed=9436040;
RX   PubMed=22460905;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Japanese.
CC   Doubling time: 47.1 hours (Note=At 31th passage), 59.3 hours (Note=At 22th passage) (PubMed=9436040).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Thr74Pro (c.220A>C); ClinVar=VCV000929160; Zygosity=Heterozygous (DepMap=ACH-000397).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg342Ter (c.1024C>T); ClinVar=VCV000182970; Zygosity=Homozygous (DepMap=ACH-000397).
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0.21%; Native American=0%; East Asian, North=76.96%; East Asian, South=22.41%; South Asian=0.11%; European, North=0%; European, South=0.3% (PubMed=30894373).
CC   Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
ST   Source(s): RCB=RCB1433
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 10,12
ST   D16S539: 11,12
ST   D5S818: 11,12
ST   D7S820: 10,12
ST   TH01: 7,8
ST   TPOX: 8
ST   vWA: 14,17
DI   NCIt; C7558; Endometrial carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   74Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 02-05-24; Version: 24
//
RX   PubMed=9436040;
RA   Fushiki H., Hidaka T., Fujimura M., Yasoshima K., Yamakawa Y.,
RA   Izumi R.;
RT   "Characterization of a newly established human tumor cell line (TEN)
RT   from a patient with clear cell carcinoma of the uterine body and its
RT   sensitivity to anti-cancer agents.";
RL   Hum. Cell 10:199-208(1997).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//