Cellosaurus logo
expasy logo

Cellosaurus SRD-2 (CVCL_E041)

[Text version]
Cell line name SRD-2
Synonyms Sterol Regulatory Defective-2
Accession CVCL_E041
Resource Identification Initiative To cite this cell line use: SRD-2 (RRID:CVCL_E041)
Comments Transformant: NCIt; C129643; Cesium-137 gamma radiation.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Sequence variations
  • Gene fusion; UniProtKB; Q60429; Srebp2 + UniProtKB; G3HX69; Lima1; Name(s)=Srebp2-Lima1; Note=In frame (PubMed=7744865).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_D893 (CHO-7)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=2570073; DOI=10.1016/S0021-9258(19)84879-2
Metherall J.E., Goldstein J.L., Luskey K.L., Brown M.S.
Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells.
J. Biol. Chem. 264:15634-15641(1989)

PubMed=1673968; DOI=10.1016/S0021-9258(18)31560-6
Dawson P.A., Metherall J.E., Ridgway N.D., Brown M.S., Goldstein J.L.
Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
J. Biol. Chem. 266:9128-9134(1991)

PubMed=7744865; DOI=10.1074/jbc.270.20.12152
Yang J.-X., Brown M.S., Ho Y.K., Goldstein J.L.
Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution.
J. Biol. Chem. 270:12152-12161(1995)

Cross-references
Encyclopedic resources Wikidata; Q54955660
Entry history
Entry creation22-Oct-2012
Last entry update30-Jan-2024
Version number13