ID   SRD-2
AC   CVCL_E041
SY   Sterol Regulatory Defective-2
DR   Wikidata; Q54955660
RX   PubMed=1673968;
RX   PubMed=2570073;
RX   PubMed=7744865;
CC   Sequence variation: Gene fusion; UniProtKB; Q60429; Srebp2 + UniProtKB; G3HX69; Lima1; Name(s)=Srebp2-Lima1; Note=In frame (PubMed=7744865).
CC   Transformant: NCIt; C129643; Cesium-137 gamma radiation.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_D893 ! CHO-7
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 22-10-12; Last updated: 30-01-24; Version: 13
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RX   PubMed=1673968; DOI=10.1016/S0021-9258(18)31560-6;
RA   Dawson P.A., Metherall J.E., Ridgway N.D., Brown M.S., Goldstein J.L.;
RT   "Genetic distinction between sterol-mediated transcriptional and
RT   posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A
RT   reductase.";
RL   J. Biol. Chem. 266:9128-9134(1991).
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RX   PubMed=2570073; DOI=10.1016/S0021-9258(19)84879-2;
RA   Metherall J.E., Goldstein J.L., Luskey K.L., Brown M.S.;
RT   "Loss of transcriptional repression of three sterol-regulated genes in
RT   mutant hamster cells.";
RL   J. Biol. Chem. 264:15634-15641(1989).
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RX   PubMed=7744865; DOI=10.1074/jbc.270.20.12152;
RA   Yang J.-X., Brown M.S., Ho Y.K., Goldstein J.L.;
RT   "Three different rearrangements in a single intron truncate sterol
RT   regulatory element binding protein-2 and produce sterol-resistant
RT   phenotype in three cell lines. Role of introns in protein evolution.";
RL   J. Biol. Chem. 270:12152-12161(1995).
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