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Cellosaurus SRD-1 (CVCL_E040)

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Cell line name SRD-1
Synonyms Sterol Regulatory Defective-1
Accession CVCL_E040
Resource Identification Initiative To cite this cell line use: SRD-1 (RRID:CVCL_E040)
Comments Transformant: ChEBI; CHEBI_23995; N-ethyl-N-nitrosourea (ENU).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Sequence variations
  • Gene fusion; UniProtKB; Q60429; Srebf2 + UniProtKB; G3IJJ1; Xrcc6; Name(s)=Srebf2-Xrcc6, Srebp2-Xrcc6, Srebp-2/Ku p70; Note=Out of frame (PubMed=7744865).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_D893 (CHO-7)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=2570073; DOI=10.1016/S0021-9258(19)84879-2
James E. Metherall, Joseph Leonard Goldstein, Kenneth Lee Luskey, Michael Stuart Brown;
Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells.
J. Biol. Chem. 264:15634-15641(1989)

PubMed=7958866; DOI=10.1101/gad.8.16.1910
Jian-Xin Yang, Ryuichiro Sato, Joseph Leonard Goldstein, Michael Stuart Brown;
Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.
Genes Dev. 8:1910-1919(1994)

PubMed=7744865; DOI=10.1074/jbc.270.20.12152
Jian-Xin Yang, Michael Stuart Brown, Y.K. Ho, Joseph Leonard Goldstein;
Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution.
J. Biol. Chem. 270:12152-12161(1995)

Cross-references
Encyclopedic resources Wikidata; Q54955654
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number15