ID   SRD-1
AC   CVCL_E040
SY   Sterol Regulatory Defective-1
DR   Wikidata; Q54955654
RX   PubMed=2570073;
RX   PubMed=7744865;
RX   PubMed=7958866;
CC   Sequence variation: Gene fusion; UniProtKB; Q60429; Srebp2 + UniProtKB; G3IJJ1; Xrcc6; Name(s)=Srebp2-Xrcc6, Srebp-2/Ku p70; Note=Out of frame (PubMed=7744865).
CC   Transformant: ChEBI; CHEBI:23995; N-ethyl-N-nitrosourea (ENU).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_D893 ! CHO-7
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 22-10-12; Last updated: 30-01-24; Version: 12
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RX   PubMed=2570073; DOI=10.1016/S0021-9258(19)84879-2;
RA   Metherall J.E., Goldstein J.L., Luskey K.L., Brown M.S.;
RT   "Loss of transcriptional repression of three sterol-regulated genes in
RT   mutant hamster cells.";
RL   J. Biol. Chem. 264:15634-15641(1989).
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RX   PubMed=7744865; DOI=10.1074/jbc.270.20.12152;
RA   Yang J.-X., Brown M.S., Ho Y.K., Goldstein J.L.;
RT   "Three different rearrangements in a single intron truncate sterol
RT   regulatory element binding protein-2 and produce sterol-resistant
RT   phenotype in three cell lines. Role of introns in protein evolution.";
RL   J. Biol. Chem. 270:12152-12161(1995).
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RX   PubMed=7958866; DOI=10.1101/gad.8.16.1910;
RA   Yang J.-X., Sato R., Goldstein J.L., Brown M.S.;
RT   "Sterol-resistant transcription in CHO cells caused by gene
RT   rearrangement that truncates SREBP-2.";
RL   Genes Dev. 8:1910-1919(1994).
//