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Cellosaurus 451F3 (CVCL_DP98)

[Text version]
Cell line name 451F3
Synonyms 451F-3
Accession CVCL_DP98
Resource Identification Initiative To cite this cell line use: 451F3 (RRID:CVCL_DP98)
Comments From: Center for iPS Cell Research and Application, Kyoto University; Kyoto; Japan.
Population: Japanese.
Omics: Genomics; DNA methylation analysis.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Tooth, dental pulp; UBERON=UBERON_0001754.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Leu (c.818G>T); ClinVar=VCV000376655; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_DP68 (DP074)
Sex of cell Female
Age at sampling 16Y
Category Induced pluripotent stem cell
Publications

PubMed=21460823; DOI=10.1038/nmeth.1591
Keisuke Okita, Yasuko Matsumura, Yoshiko Sato, Atsumasa Okada, Asuka Morizane, Satoshi Okamoto, Hyen-Jong Hong, Masato Nakagawa, Koji Tanabe, Ken-ichi Tezuka, Toshiyuki Shibata ...Show all 16 authors... , Takahiro Kunisada, Masayo Takahashi, Jun Takahashi, Hiroh Saji, Shinya Yamanaka; Show fewer authors
A more efficient method to generate integration-free human iPS cells.
Nat. Methods 8:409-412(2011)

PubMed=22802639; DOI=10.1073/pnas.1209979109; PMCID=PMC3411998
Masatoshi Kajiwara, Takashi Aoi, Keisuke Okita, Ryosuke Takahashi, Haruhisa Inoue, Naoya Takayama, Hiroshi Endo, Koji Eto, Junya Toguchida, Shinji Uemoto, Shinya Yamanaka;
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells.
Proc. Natl. Acad. Sci. U.S.A. 109:12538-12543(2012)

PubMed=24259714; DOI=10.1073/pnas.1319061110; PMCID=PMC3870695
Michiyo Koyanagi-Aoi, Mari Ohnuki, Kazutoshi Takahashi, Keisuke Okita, Hisashi Noma, Yuka Sawamura, Ito Teramoto, Megumi Narita, Yoshiko Sato, Tomoko Ichisaka, Naoki Amano ...Show all 17 authors... , Akira Watanabe, Asuka Morizane, Yasuhiro Yamada, Tosiya Sato, Jun Takahashi, Shinya Yamanaka; Show fewer authors
Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells.
Proc. Natl. Acad. Sci. U.S.A. 110:20569-20574(2013)

PubMed=27476965; DOI=10.1016/j.stem.2016.06.019
Masatoshi Nishizawa, Kazuhisa Chonabayashi, Masaki Nomura, Azusa Tanaka, Masahiro Nakamura, Azusa Inagaki, Misato Nishikawa, Ikue Takei, Akiko Oishi, Koji Tanabe, Mari Ohnuki ...Show all 18 authors... , Hidaka Yokota, Michiyo Koyanagi-Aoi, Keisuke Okita, Akira Watanabe, Akifumi Takaori-Kondo, Shinya Yamanaka, Yoshinori Yoshida; Show fewer authors
Epigenetic variation between human induced pluripotent stem cell lines is an indicator of differentiation capacity.
Cell Stem Cell 19:341-354(2016)

PubMed=28445466; DOI=10.1038/nature22312; PMCID=PMC5427175
Florian T. Merkle, Sulagna Ghosh, Nolan Kamitaki, Jana Mitchell, Yishai Avior, Curtis Mello, Seva Kashin, Shila Mekhoubad, Dusko Ilic, Maura Charlton, Genevieve Saphier ...Show all 17 authors... , Robert E. Handsaker, Giulio Genovese, Shiran Bar, Nissim Benvenisty, Steven A. McCarroll, Kevin Carl Eggan; Show fewer authors
Human pluripotent stem cells recurrently acquire and expand dominant negative p53 mutations.
Nature 545:229-233(2017)

Cross-references
Cell line databases/resources SKIP; SKIP005492
Encyclopedic resources Wikidata; Q54603176
Gene expression databases GEO; GSM1040277
GEO; GSM1040347
GEO; GSM1489197
GEO; GSM1489241
GEO; GSM1489432
Entry history
Entry creation13-Jul-2016
Last entry update10-Apr-2025
Version number14