ID   451F3
AC   CVCL_DP98
SY   451F-3
DR   GEO; GSM1040277
DR   GEO; GSM1040347
DR   GEO; GSM1489197
DR   GEO; GSM1489241
DR   GEO; GSM1489432
DR   SKIP; SKIP005492
DR   Wikidata; Q54603176
RX   PubMed=21460823;
RX   PubMed=22802639;
RX   PubMed=24259714;
RX   PubMed=27476965;
RX   PubMed=28445466;
CC   From: Center for iPS Cell Research and Application, Kyoto University; Kyoto; Japan.
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273Leu (c.818G>T); ClinVar=VCV000376655; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
CC   Omics: DNA methylation analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Tooth, dental pulp; UBERON=UBERON_0001754.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_DP68 ! DP074
SX   Female
AG   16Y
CA   Induced pluripotent stem cell
DT   Created: 13-07-16; Last updated: 29-06-23; Version: 12
//
RX   PubMed=21460823; DOI=10.1038/nmeth.1591;
RA   Okita K., Matsumura Y., Sato Y., Okada A., Morizane A., Okamoto S.,
RA   Hong H.-J., Nakagawa M., Tanabe K., Tezuka K.-i., Shibata T.,
RA   Kunisada T., Takahashi M., Takahashi J., Saji H., Yamanaka S.;
RT   "A more efficient method to generate integration-free human iPS
RT   cells.";
RL   Nat. Methods 8:409-412(2011).
//
RX   PubMed=22802639; DOI=10.1073/pnas.1209979109;
RA   Kajiwara M., Aoi T., Okita K., Takahashi R., Inoue H., Takayama N.,
RA   Endo H., Eto K., Toguchida J., Uemoto S., Yamanaka S.;
RT   "Donor-dependent variations in hepatic differentiation from
RT   human-induced pluripotent stem cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12538-12543(2012).
//
RX   PubMed=24259714; DOI=10.1073/pnas.1319061110;
RA   Koyanagi-Aoi M., Ohnuki M., Takahashi K., Okita K., Noma H.,
RA   Sawamura Y., Teramoto I., Narita M., Sato Y., Ichisaka T., Amano N.,
RA   Watanabe A., Morizane A., Yamada Y., Sato T., Takahashi J.,
RA   Yamanaka S.;
RT   "Differentiation-defective phenotypes revealed by large-scale analyses
RT   of human pluripotent stem cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20569-20574(2013).
//
RX   PubMed=27476965; DOI=10.1016/j.stem.2016.06.019;
RA   Nishizawa M., Chonabayashi K., Nomura M., Tanaka A., Nakamura M.,
RA   Inagaki A., Nishikawa M., Takei I., Oishi A., Tanabe K., Ohnuki M.,
RA   Yokota H., Koyanagi-Aoi M., Okita K., Watanabe A., Takaori-Kondo A.,
RA   Yamanaka S., Yoshida Y.;
RT   "Epigenetic variation between human induced pluripotent stem cell
RT   lines is an indicator of differentiation capacity.";
RL   Cell Stem Cell 19:341-354(2016).
//
RX   PubMed=28445466; DOI=10.1038/nature22312;
RA   Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C.,
RA   Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G.,
RA   Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A.,
RA   Eggan K.C.;
RT   "Human pluripotent stem cells recurrently acquire and expand dominant
RT   negative P53 mutations.";
RL   Nature 545:229-233(2017).
//