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Cellosaurus LAMA84-rn (CVCL_DP54)

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Cell line name LAMA84-rn
Accession CVCL_DP54
Resource Identification Initiative To cite this cell line use: LAMA84-rn (RRID:CVCL_DP54)
Comments Selected for resistance to: ChEBI; CHEBI_52172; Nilotinib (AMN107; Tasigna).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys319Ter (c.955A>T); Zygosity=Homozygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0388 (LAMA-84)
Sex of cell Female
Age at sampling 29Y
Category Cancer cell line
Publications

PubMed=19047160; DOI=10.1158/0008-5472.CAN-08-1008
Francois-Xavier Mahon, Sandrine Hayette, Valerie Lagarde, Francis Belloc, Beatrice Turcq, Franck Nicolini, Coralie Belanger, Paul W. Manley, Cedric Leroy, Gabriel Etienne, Serge Roche, Jean-Max Pasquet;
Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression.
Cancer Res. 68:9809-9816(2008)

Cross-references
Encyclopedic resources Wikidata; Q54901918
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number13