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Cellosaurus Jones (CVCL_DN28)

[Text version]
Cell line name Jones
Synonyms JONES
Accession CVCL_DN28
Resource Identification Initiative To cite this cell line use: Jones (RRID:CVCL_DN28)
Comments Part of: FACC canine tumor cell line panel.
Doubling time: 14 hours (PubMed=27257868).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Mutation; VGNC; 38196; ASXL1; Simple; p.Gly618fs (c.1850dupG); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; 43959; NRAS; Simple; p.Gln61Arg (c.182A>G); Zygosity=Heterozygous (PubMed=27197945; PubMed=31175136).
  • Mutation; VGNC; 44567; PTEN; Simple; p.Asp246fs (c.734dupA); Zygosity=Heterozygous (PubMed=31175136).
Disease Canine melanoma (NCIt: C120298)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Markers:
Dog FHC2010235,239
Dog FHC2054168,172
Dog FHC2079271,279
Dog PEZ1123
Dog PEZ12267,270
Dog PEZ20180
Dog PEZ3127,129
Dog PEZ5103,111
Dog PEZ6183,191
Dog PEZ8240

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Publications

PubMed=27257868; DOI=10.1371/journal.pone.0156689
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=26842912; DOI=10.1111/vco.12197
Hartley G., Faulhaber E.A., Caldwell A., Coy J., Kurihara J.N., Guth A., Regan D.P., Dow S.W.
Immune regulation of canine tumour and macrophage PD-L1 expression.
Vet. Comp. Oncol. 15:534-549(2017)

PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Cross-references
Encyclopedic resources Wikidata; Q54899042
Gene expression databases GEO; GSM1974791
Entry history
Entry creation13-Jul-2016
Last entry update21-Mar-2023
Version number10