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Cellosaurus OVCAR3-533533-R7 (CVCL_DH41)

[Text version]
Cell line name OVCAR3-533533-R7
Accession CVCL_DH41
Resource Identification Initiative To cite this cell line use: OVCAR3-533533-R7 (RRID:CVCL_DH41)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:132239; PHA-533533.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 8979; PIK3R1; Simple; c.1746-2A>T; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0465 (OVCAR-3)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
Publications

PubMed=24004674; DOI=10.1158/1078-0432.CCR-13-1337
Etemadmoghadam D., Au-Yeung G., Wall M., Mitchell C., Kansara M., Loehrer E., Batzios C., George J., Ftouni S., Weir B.A., Carter S., Gresshoff I., Mileshkin L., Rischin D., Hahn W.C., Waring P.M., Getz G., Cullinane C., Campbell L.J., Bowtell D.D.L.
Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer.
Clin. Cancer Res. 19:5960-5971(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DH41
Encyclopedic resources Wikidata; Q54937022
Gene expression databases GEO; GSM1186821
GEO; GSM1186826
GEO; GSM1186832
Polymorphism and mutation databases Progenetix; CVCL_DH41
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number12