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Cellosaurus OVCAR3-533533-R5 (CVCL_DH39)

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Cell line name OVCAR3-533533-R5
Accession CVCL_DH39
Resource Identification Initiative To cite this cell line use: OVCAR3-533533-R5 (RRID:CVCL_DH39)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_132239; PHA-533533.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; c.1746-2A>T; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0465 (OVCAR-3)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
Publications

PubMed=24004674; DOI=10.1158/1078-0432.CCR-13-1337
Dariush Etemadmoghadam, George Au-Yeung, Meaghan Wall, Chris Mitchell, Maya Kansara, Elizabeth Loehrer, Crisoula Batzios, Joshy George, Sarah Ftouni, Barbara A. Weir, Scott Carter ...Show all 20 authors... , Irma L. Gresshoff, Linda Mileshkin, Danny Rischin, William Chun Hahn, Paul M. Waring, Gad Getz, Carleen Cullinane, Lynda J. Campbell, David D.L. Bowtell; Show fewer authors
Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer.
Clin. Cancer Res. 19:5960-5971(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DH39
Encyclopedic resources Wikidata; Q54937020
Gene expression databases GEO; GSM1186819
GEO; GSM1186824
GEO; GSM1186830
Polymorphism and mutation databases Progenetix; CVCL_DH39
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number13